Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
![Molecules | Free Full-Text | Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents | HTML Molecules | Free Full-Text | Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents | HTML](https://www.mdpi.com/molecules/molecules-23-02602/article_deploy/html/images/molecules-23-02602-g002.png)
Molecules | Free Full-Text | Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents | HTML
![Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site | eLife Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site | eLife](https://iiif.elifesciences.org/lax/56519%2Felife-56519-fig5-v2.tif/full/,1500/0/default.jpg)
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site | eLife
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses | Journal of Neuroscience κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses | Journal of Neuroscience](https://www.jneurosci.org/content/jneuro/23/13/5674/F2.large.jpg)
κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses | Journal of Neuroscience
![Effects of Mixed-Action κ/μ Opioids on Cocaine Self-Administration and Cocaine Discrimination by Rhesus Monkeys | Neuropsychopharmacology Effects of Mixed-Action κ/μ Opioids on Cocaine Self-Administration and Cocaine Discrimination by Rhesus Monkeys | Neuropsychopharmacology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fsj.npp.1300105/MediaObjects/41386_2003_Article_BF1300105_Fig1_HTML.gif)
Effects of Mixed-Action κ/μ Opioids on Cocaine Self-Administration and Cocaine Discrimination by Rhesus Monkeys | Neuropsychopharmacology
![Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences](https://www.cell.com/cms/attachment/763e3174-aa34-42c8-9d54-6c4b4c4be691/gr1_lrg.jpg)
Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences
![Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2020/07/29/2020.07.28.225060/F3.large.jpg)
Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv
![Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity - ScienceDirect Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0896627313000421-gr7.jpg)
Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity - ScienceDirect
![The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - Biological Psychiatry The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - Biological Psychiatry](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/41f7705e-1cce-421f-95db-2a80a3f1edd3/gr1.jpg)
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - Biological Psychiatry
![Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats - Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats -](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/e7593d0f-54bb-40dc-96e0-4241eace8d16/gr1_lrg.jpg)
Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats -
![κ Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake | Journal of Neuroscience κ Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake | Journal of Neuroscience](https://www.jneurosci.org/content/jneuro/35/10/4296/F2.large.jpg)
κ Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake | Journal of Neuroscience
![Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration | Neuropsychopharmacology Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1016%2FS0893-133X%2800%2900190-1/MediaObjects/41386_2001_Article_BF1395598_Fig1_HTML.jpg)
Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration | Neuropsychopharmacology
![Frontiers | Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research Frontiers | Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research](https://www.frontiersin.org/files/Articles/582147/fnbeh-14-582147-HTML/image_m/fnbeh-14-582147-g001.jpg)
Frontiers | Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research
![Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex | Scientific Reports Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-021-81955-5/MediaObjects/41598_2021_81955_Fig1_HTML.png)
Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex | Scientific Reports
![Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2020/07/29/2020.07.28.225060/F2.large.jpg)
Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration | bioRxiv
![A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41386-017-0006-4/MediaObjects/41386_2017_6_Fig3_HTML.jpg)
A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology
![Interactions between Kappa Opioid Agonists and Cocaine: Preclinical Studies - MELLO - 2000 - Annals of the New York Academy of Sciences - Wiley Online Library Interactions between Kappa Opioid Agonists and Cocaine: Preclinical Studies - MELLO - 2000 - Annals of the New York Academy of Sciences - Wiley Online Library](https://nyaspubs.onlinelibrary.wiley.com/cms/asset/11483974-9c1c-4147-9ea6-5c0fb465822d/nyas_104_f2.gif)
Interactions between Kappa Opioid Agonists and Cocaine: Preclinical Studies - MELLO - 2000 - Annals of the New York Academy of Sciences - Wiley Online Library
![A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-017-0006-4/MediaObjects/41386_2017_6_Fig1_HTML.jpg)
A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology
![Self-Administered Heroin and Cocaine Combinations in the Rat: Additive Reinforcing Effects—Supra-Additive Effects on Nucleus Accumbens Extracellular Dopamine | Neuropsychopharmacology Self-Administered Heroin and Cocaine Combinations in the Rat: Additive Reinforcing Effects—Supra-Additive Effects on Nucleus Accumbens Extracellular Dopamine | Neuropsychopharmacology](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fsj.npp.1300786/MediaObjects/41386_2006_Article_BF1300786_Fig1_HTML.gif)
Self-Administered Heroin and Cocaine Combinations in the Rat: Additive Reinforcing Effects—Supra-Additive Effects on Nucleus Accumbens Extracellular Dopamine | Neuropsychopharmacology
![Frontiers | Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self- administration through Nociceptin Opioid and Mu Opioid Receptors Frontiers | Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self- administration through Nociceptin Opioid and Mu Opioid Receptors](https://www.frontiersin.org/files/Articles/310325/fpsyt-08-00234-HTML/image_m/fpsyt-08-00234-g001.jpg)
Frontiers | Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self- administration through Nociceptin Opioid and Mu Opioid Receptors
![Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling](https://www.science.org/cms/asset/35d59cc9-5e24-4990-b0eb-4fc248e3274c/9_ra117_f1.gif)